CoreLogic Launches Insights Mobile App

first_img in Headlines, News, Technology Share CoreLogic Insights App Service Provider 2015-11-05 Staff Writer CoreLogic, a global property information, analytics, and data-enabled services provider, recently announced that it has come out with their Insights App, a mobile app designed to enhance user perspective on U.S. and international property markets.Headquartered in Irvine, California, CoreLogic provides clients with assistance in identifying and managing growth opportunities, improving performance and mitigating risk in the real estate and mortgage finance, insurance, capital markets, and public sectors.The Insights App is designed to help mortgage business leaders, investors, analysts, and government policy makers gain continual access to mortgage, real estate and housing economy property intelligence, trends, and analysis. The app has a geographically configurable market metrics dashboard that enables users to monitor CoreLogic property data, including home price indices, homeowner equity, along with days on market and median sales prices.“The pace of change in the real estate economy is accelerating. More than ever, access to cutting-edge insights anytime, anywhere is essential to seizing opportunities and arresting risks,” said Olumide Soroye, managing director of Information Solutions for CoreLogic, via a press release from the company. “The Insights App connects users to property intelligence, market developments and trends that are important to business and regulatory leaders in shaping the real estate economy and as homeowners. This is an important step forward in our ongoing commitment to power the real estate economy with unique property insights delivered through next generation technologies.”In addition, the Insights App also includes blog posts and research publications containing original analysis and commentary authored by CoreLogic industry experts and data scientists.The app is available for download in the Apple App Store and Google Play for Android. For more information and details, visit November 5, 2015 466 Views CoreLogic Launches Insights Mobile Applast_img read more

Biologists identify the backup systems that ensure genes build limbs

first_img Click to view the privacy policy. Required fields are indicated by an asterisk (*) Sign up for our daily newsletter Get more great content like this delivered right to you! Country Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe COLD SPRING HARBOR, NEW YORK—Some aspects of our genomes would make a NASA engineer proud. Whereas spacecraft have many redundant systems that can kick in, such as when a thruster fails, cells have their own backup systems for regulating gene activity. But they are extraordinarily hard to understand, as was made clear last week when molecular biologists for the first time described the regulatory backups for two genes involved in mammalian limb formation. Understanding these redundancies, and how to bypass them, could be important for biomedical researchers wishing to manipulate gene activity to treat human diseases.Genes may carry information for building proteins, but a host of other factors, including the DNA between genes that doesn’t encode proteins, tells them when to make their proteins. And this so-called noncoding DNA plays a role in some diseases, studies have shown. Noncoding DNA includes stretches called enhancers, short sequences that help control a target gene.  Geneticists have identified hundreds of thousands of potential enhancers in our genome, but verifying their role in DNA regulation and disease is a daunting proposition. “We still don’t have a good understanding of what [many do],” says Yang Li, a computational biologist at Stanford University in Palo Alto, California.For the new study, presented last week at the Biology of Genomes meeting here, molecular biologist Marco Osterwalder of Lawrence Berkeley National Laboratory in Berkeley, California, and colleagues harnessed a powerful new gene-editing technique called CRISPR to figure out exactly how some of these candidate enhancers work. The method speeds up the development of “knockout” mice that lack a particular enhancer, helping reveal its function.center_img The lab already had preliminary evidence for more than 1200 enhancers. And in the new tests, Osterwalder used CRISPR to knock out 10 of the enhancers in different mouse embryos. These enhancers were located close to genes involved in limb development, so he and his colleagues expected the embryo’s limbs to be defective in some way. But to their dismay, there were no such abnormalities, he reported last week. Wondering whether other enhancers pick up the slack—providing a backup system to keep limb development on track—Osterwalder and his colleagues bred mice lacking a pair of enhancers specifically implicated in digit formation.  Those mouse embryos developed extra digits, just as an embryo would have if the enhancers’ target gene, Gli3, itself had been defective, he reported at the meeting.To further explore this redundancy, the team then knocked out one or both of those enhancers in mice in which they had also knocked out one of the pair of Gli3 genes that control digit number. Typically, with one copy of that gene out of commission, embryos make only half the normal amount of Gli3 protein—and an extra thumb forms. When scientists also knocked out just one of the enhancers in the same mice, the embryos again grew an extra thumb. But when scientists knocked out both enhancers in the mice with one missing Gli3, the mice grew several extra digits. Those results are the same if the enhancers are intact but both copies of the gene itself are defective, indicating that the amount of protein determines the number of digits. The enhancers “are redundant on an organismal level, but additive at a molecular level,” Osterwalder concluded. “It is really a wonderful experiment” says William Greenleaf, a biophysicist at Stanford who was not involved with the work. “It represents the logical next step in the mapping of regulatory elements.”Three years ago, another team studying enhancers in the development of the mouse face and skull uncovered similar complexity. And studies in Drosophila suggest, too, that interactions of multiple enhancers are commonplace. Already, researchers have linked noncoding DNA to Crohn disease, heart disease, multiple sclerosis, and other disorders, suggesting that enhancers could be targets for medical manipulation. And “we are finding more associations all the time,” says Joseph Pickrell, an evolutionary geneticist at the New York Genome Center in New York City. But given the complexity revealed by the CRISPR experiments, understanding how enhancers interact with diseases “is going to be a marathon,” he predicts. Emaillast_img read more