10 months agoMerson: Liverpool can end title race in week’s time

first_imgMerson: Liverpool can end title race in week’s timeby Paul Vegas10 months agoSend to a friendShare the loveArsenal hero Paul Merson says Liverpool can win the Premier League title in a week’s time.Merson believes if Liverpool win at the Etihad Stadium next month, a seven-point lead would be too much for Pep Guardiola’s Manchester City to overturn.He said, “Leicester vs Manchester City is a big game and a must-win game for City, who are in trouble now as they are four points behind Liverpool.”I mean it has now got down to the situation whereby if Liverpool win at City in a week’s time – it is all over.”So this is a big game for City and a hard one as Leicester can cause you problems But because they have to win, I think they will, but Saturday’s result will have knocked the stuffing out of them and Man City have now lost two of their last three league games.”And before that it looked like they would never ever lose a game, but I see them just winning this one to stay on the coat tails of Liverpool.” About the authorPaul VegasShare the loveHave your saylast_img read more

25 days agoRodgers plays down Leicester top-four chances

first_imgAbout the authorPaul VegasShare the loveHave your say Rodgers plays down Leicester top-four chancesby Paul Vegas25 days agoSend to a friendShare the loveBrendan Rodgers has played down Leicester City’s chances of breaking into the top-four.The Foxes were in scintillating form in Sunday’s 5-0 thrashing of Newcastle United.The win leaves the 2016 Premier League title winners in third place, but Rodgers has cooled expectations of his side.”It’s very early in the season,” said the Northern Irishman.”We know it’s a big ask because of all the other clubs that have been regulars there. We are only really focusing on how we play, looking at our performance levels.” last_img read more

Researchers identify cause of inherited metabolic disorder

first_imgReviewed by James Ives, M.Psych. (Editor)Apr 16 2019A new study from BC Children’s Hospital, the University of British Columbia (UBC) and an international team of researchers published in the New England Journal of Medicine is the first to identify a rarely-seen type of DNA mutation as the cause of an inherited metabolic disorder.Inherited metabolic disorders — where the body can’t break down specific nutrients from food leading to a range of serious health problems — are often caused by a defective gene.In this important study, researchers found an unusual genetic mutation behind three children’s undiagnosed, degenerative conditions: a repeat expansion of DNA. In this specific mutation, the gene appears undamaged but does not function because the DNA adjacent to it has extended several hundred times its normal length.”To detect this kind of DNA multiplication, you can only use whole genome sequencing and have to search through billions of pieces of DNA; it’s truly a search for the needle in the haystack,” said lead author Dr. Clara van Karnebeek. “With our new approach we have finally solved our mystery cases, and we now expect to find the genetic cause of other, as of yet unexplained, genetic metabolic diseases.”To date, DNA repeat expansions have been linked to approximately 30 different diseases.”For kids with rare diseases and their families, finding the root causes of their disorders is tremendously important,” said Dr. Wyeth Wasserman, a co-author of the study. “A diagnosis gives us the potential to intervene, relieves undeserved parental guilt, and provides insights into more common diseases.”For a child with an unexplained medical condition, a diagnosis lays the groundwork for further research that could lead to new interventions such as gene therapy aimed at “turning on” the impaired gene, dietary modification or supplements that provide the nutrients the body is missing. Effective treatment can slow or stop damaging symptoms, improving the quality of life of children with rare disorders and their families.In this study, initial work by van Karnebeek and her research team narrowed the search for the genetic causes of this rare disorder to key areas of the genome. However, after further investigations using exome sequencing and whole genome sequencing, the international research team couldn’t pinpoint the error in the DNA.Related StoriesMolecular switches may control lifespan and healthspan separately, genetic discovery suggestsFungal infection study identifies specific genetic vulnerability among Hmong peopleResearchers identify gene mutations linked to leukemia in children with Down’s syndromeIt’s here that researchers at BC Children’s took a novel approach. Through in-depth, manual analysis and the use of emerging bioinformatics tools and techniques study co-authors Dr. Britt Drögemöller and Phillip Richmond discovered and confirmed that the gene responsible for the disorder was intact but a repeat expansion error prevented it from functioning.”In our search, we focused on variations that would have been hard to discover through exome sequencing” said Drögemöller. “After months of experimenting with various different analyses, we finally uncovered this novel genetic variant by using new targeted approaches aimed at identifying DNA repeat expansions.””These findings were made possible by a multidisciplinary approach and advances in technology, techniques and software,” said Richmond. “It wouldn’t have been possible as recently as two years ago and, most importantly, it shows us what to look for in other undiagnosed cases.”The gene identified as the cause of this particular disorder is an enzyme that enables the body to turn an amino acid called glutamine into glutamate. More work is needed to determine how exactly this genetic error leads to disease, but it’s likely that either a build-up of glutamine or the lack of glutamate caused the children’s serious developmental delays and disabilities including difficulty with language, speech, balance and coordination.Through collaborations with sequencing consortiums around the world, researchers were able to confirm that this particular repeat expansion was found in only 1 in 8,000 people, establishing the mutation as very rare.Over one million Canadians suffer from a rare disease and in over 50 per cent of these cases, the underlying genetic cause of the illness remains unknown.”We can do better for children with rare diseases. For the 50 per cent who can’t find answers, this discovery and new approach will help us dig in and potentially find the causes of their disease,” said Richmond. Source:https://www.ubc.ca/last_img read more

Pliable microbatteries for wearables

first_img Flexible batteries a highlight for smart dental aids In its development of batteries for wearables, Fraunhofer IZM combines new approaches and years of experience with a customer-tailored development process: “We work with companies to develop the right battery for them,” explains the graduate electrical engineer. The team consults closely with customers to draw up the energy requirements. They carefully adapt parameters such as shape, size, voltage, capacity and power and combined them to form a power supply concept. The team also carries out customer-specific tests.Smart plaster to measure sweatIn 2018, the institute began work on a new wearable technology, the smart plaster. Together with Swiss sensor manufacturer Xsensio, this EU-sponsored project aims to develop a plaster that can directly measure and analyze the patient’s sweat. This can then be used to draw conclusions about the patient’s general state of health. In any case, having a convenient, real-time analysis tool is the ideal way to better track and monitor healing processes. Fraunhofer IZM is responsible for developing the design concept and energy supply system for the sweat measurement sensors. The plan is to integrate sensors that are extremely flat, light and flexible. This will require the development of various new concepts. One idea, for instance, would be an encapsulation system made out of aluminum composite foil. The researchers also need to ensure they select materials that are inexpensive and easy to dispose of. After all, a plaster is a disposable product. Fabrication of micro batteries with side-by side electrodes on silicon wafer. Credit: Fraunhofer IZM Explore further Success through segmentationRobert Hahn, a researcher in Fraunhofer IZM’s department for RF & Smart Sensor Systems, explains why segmentation is the recipe for success: “If you make a battery extremely pliable, it will have very poor energy density – so it’s much better to adopt a segmented approach.”Instead of making the batteries extremely pliable at the cost of energy density and reliability, the institute turned its focus to designing very small and powerful batteries and optimized mounting technology. The batteries are pliable in between segments. In other words, the smart band is flexible while retaining a lot more power than other smart wristbands available on the market. Citation: Pliable micro-batteries for wearables (2018, October 1) retrieved 17 July 2019 from https://phys.org/news/2018-10-pliable-micro-batteries-wearables.html In medicine, wearables are used to collect data without disturbing patients as they go about their daily business – to record long-term ECGs, for instance. Since the sensors are light, flexible and concealed in clothing, this is a convenient way to monitor a patient’s heartbeat. The technology also has more everyday applications – fitness bands, for instance, that measure joggers’ pulses while out running. There is huge growth potential in the wearables sector, which is expected to reach a market value of 72 billion euros by 2020.How to power these smart accessories poses a significant technical challenge. There are the technical considerations – durability and energy density – but also material requirements such as weight, flexibility and size, and these must be successfully combined. This is where Fraunhofer IZM comes in: experts at the institute have developed a prototype for a smart wristband that, quite literally, collects data first hand. The silicone band’s technical piece de resistance is its three gleaming green batteries. Boasting a capacity of 300 milliampere hours, these batteries are what supply the wristband with power. They can store energy of 1.1 watt hours and lose less than three percent of their charging capacity per year. With these parameters the new prototype has a much higher capacity than smart bands available at the market so far, enabling it to supply even demanding portable electronics with energy. The available capacity is actually sufficient to empower a conventional smart watch at no runtime loss. With these sorts of stats, the prototype beats established products such as smart watches, in which the battery is only built into the watch casing and not in the strap. There is a new technology gripping the markets of the future – technology to wear. Wearables, as they are known, are portable systems that contain sensors to collect measurement data from our bodies. Powering these sensors without wires calls for pliable batteries that can adapt to the specific material and deliver the power the system requires. Micro-batteries developed by the Fraunhofer Institute for Reliability and Microintegration IZM provide the technical foundation for this new technology trend. Mechanically flexible micro battery stripe made from segmented battery cells. Credit: Fraunhofer IZM Customer-tailored solutions Millimeter-sized lithium-ion batteries with interdigital electrodes. Credit: Fraunhofer IZM, Volker Mai Provided by Fraunhofer-Gesellschaft This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

US launches probe of Frances planned tech giants tax

first_img Citation: US launches probe of France’s planned tech giants tax (2019, July 11) retrieved 17 July 2019 from https://phys.org/news/2019-07-probe-france-tech-giants-tax.html © 2019 AFP The probe into unfair trade practices could pave the way for Washington to impose punitive tariffs—something Trump has done repeatedly since taking office. And it adds yet another bone of contention in the transatlantic trade disputes that now also include trade in steel, aluminum, automobiles, aircraft and agriculture.”The United States is very concerned that the digital services tax which is expected to pass the French Senate tomorrow unfairly targets American companies,” US Trade Representative Robert Lighthizer said in a statement.The proposed three percent tax on total annual revenues of companies providing services to French consumers only applies to the largest tech companies, “where US firms are global leaders,” the trade representative’s office said.Some internet heavyweights have taken advantage of low-tax jurisdictions in places like Ireland while paying next to nothing in other countries where they derive huge profits.The so-called Section 301 investigation is the primary tool the Trump administration has used in the trade war with China to justify tariffs against what the United States says are unfair trade practices.Addressing the conundrumThe US Trade Representative’s office will hold hearings to allow for public comment on the issue over several weeks before issuing a final report with a recommendation on any actions to take.Despite the objections to the French tax proposal, however, the statement said the United States will continue to work with other advanced economies to address the conundrum of how to tax tech companies.The United States is pushing for an overarching agreement on taxation through the Group of 20 economic forum, something supported by Google.The company said last month the change would probably mean Silicon Valley tech giants would pay less in the United States and more in other jurisdictions, in a departure from the longstanding practice of paying most taxes in a company’s home country.Group of 20 finance ministers last month also said they “welcomed” proposed measures from the Organization for Economic Cooperation and Development, a forum for advanced economies, to revamp international rules on corporate taxation.”We will redouble our efforts for a consensus-based solution with a final report by 2020,” they said in a statement.The Computer & Communications Industry Association on Wednesday applauded the US Trade Representative’s move, saying the French tax would retroactively require US internet giants operating in France to turn over a percentage of their revenues from the beginning of this year and violates international trade commitments.”This is a critical step toward preventing protectionist taxes on global trade,” CCIA official Matt Schruers said in a statement.”CCIA encourages France to lead the effort toward more ambitious global tax reform, instead of the discriminatory national tax measures that harm global trade.” “The United States is very concerned that the digital services tax which is expected to pass the French Senate tomorrow unfairly targets American companies,” US Trade Representative Robert Lighthizer said in a statement Explore furthercenter_img US President Donald Trump has ordered an investigation into France’s planned tax on internet services that will hit American tech giants especially hard, officials said Wednesday. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Google endorses ‘international tax deal’ for multinationalslast_img read more

Priyanka meets Azad offers support to his struggles

first_imgMarch 13, 2019 Priyanka Gandhi Vadra COMMENT COMMENTS Amid reports that Bhim Army leader Chandrashekhar Azad will contest against Prime Minister Narendra Modi in Varanasi, Congress general secretary in-charge of Eastern Uttar Pradesh Priyanka Gandhi Vadra met him at a Meerut Hospital on Wednesday. Azad was admitted in hospital after the UP Police arrested him allegedly for violating model code of conduct.Talking to reporters after the meeting, Vadra said no political matters were discussed. When asked whether Azad will be a Congress candidate, she said she did not want to politicise the meeting. “A young man is struggling, he is raising his voice and wants society to hear his problems. This government is so audacious that it tries to repress his voice. It doesn’t want to hear the problems of youth. They have not given any jobs to youth. When they raise their voices, they are repressing it,’ she said and added that she came to express solidarity with Azad.The meeting is significant, particularly after the BSP’s decision to not have any truck with the Congress in the upcoming elections. The Congress, on the other hand, is trying to reach out to other Dalit mobilisations such as the Bhim Army. Congress General Secretary Priyanka Gandhi Vadra visits Bhim Army chief Chandrashekhar Azad at a hospital, in Meerut   –  PTI Indian National Congress SHARE SHARE EMAIL Published on SHARE All India Congress Committee (AICC)last_img read more

Barring fundamentalists Muslims want construction of Ram temple in Ayodhya Ram Vilas

first_imgBarring fundamentalists, Muslims want construction of Ram temple in Ayodhya: Ram Vilas VedantiRam Janmabhoomi Nyas member Ram Vilas Vedanti on Friday claimed barring fundamentalists, the Muslim community supports the idea of construction of a grand Ram temple in Ayodhya.advertisement Next Press Trust of India LucknowJuly 12, 2019UPDATED: July 12, 2019 22:05 IST Ram Janmabhoomi Nyas member Ram Vilas Vedanti (Image Credit: ANI)Ram Janmabhoomi Nyas member Ram Vilas Vedanti on Friday claimed barring fundamentalists, the Muslim community supports the idea of construction of a grand Ram temple in Ayodhya.”Eighty per cent Muslims, barring the fundamentalists, want that the temple be constructed at the place where Ram Lalla is installed in Ayodhya,” he told media here.”Lucknow,”The chairman of the Shia Waqf Board, Wasim Rizvi has also agreed that Ram temple be built in Ayodhya whereas the mosque can be constructed at any other Shia-majority place in he said.His comments come in the wake of the Supreme Court on Thursday seeking a report on the “progress of mediation” in the politically sensitive case of Ram Janmabhoomi-Babri Masjid land dispute in Ayodhya and said a day-to-day hearing may commence from July 25 if the court decides to conclude those proceedings.Ram Vilas Vedanti, described as working president of Ram Janmabhoomi Nyas, also said there was “nothing in the name of (Mughal ruler) Babur” in Ayodhya and that everything in the city was “in the name of Lord Ram”.”There is not even a locality, lane or ward named after Babar in Ayodhya,” he said.”Muslims need to come forward and say that Hindus should construct their temple in Ayodhya for peace, communal amity and brotherhood,” he said, adding the Sunni Waqf Board should withdraw the case.To a question, Ram Vilas Vedanti, a former BJP MP, said it was most unfortunate that in a country where Hindus constitute “90 per cent” of the population, people are fighting a case in court for the construction of Ram temple.He said no power can build a mosque where Ram Lalla is installed, adding his statement could be either taken as a ‘threat’ or ‘suggestion’.On December 6, 1992, the Babri Masjid, constructed at the disputed site in the 16th century by Shia Muslim Mir Baqi, was demolished.ALSO READ | Ayodhya land title case: SC asks mediation panel to submit report by July 18ALSO WATCH | War over Jai Shri Ram escalates in Bengal, Kumaraswamy seeks floor test, says he govt has numbers; moreFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byKritika Kashyap Tags :Follow Ram Vilas VedantiFollow AyodhyaFollow Ram templeFollow MuslimsFollow Ram Janmabhoomi Nyas Karyashalalast_img read more

Sri Lankan Navy detains 6 Indian fishermen near Delft Island

first_imgSri Lankan Navy detains 6 Indian fishermen near Delft IslandThe Lankan Naval personnel were on a routine patroladvertisement Next Asian News International RameswaramJuly 12, 2019UPDATED: July 12, 2019 14:22 IST Photo: ANISri Lankan Navy apprehended six Indian fishermen from Namputhalai near Delft Island on Friday morning.The Lankan Naval personnel were on a routine patrol onboard a Fast Attack Craft attached to the Northern Naval Command.They apprehended one country boat with six fishermen for poaching in the Sri Lankan territorial waters.Straying of Indian and Sri Lankan fishermen into each others’ waters is a recurrent problem as territories on the sea are not clearly demarcated.Also read: 27 Indian fishermen arrested by Sri Lankan navyALSO WATCH| Sri Lankan Navy arrests 12 Indian fishermenFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byIram Ara Ibrahimlast_img read more